By the time fascics develop in ALS, you should see a good deal of neurogenic potentials I have read there is a connection (in ALS) between abnormal motor units (large amplitude) and the appearance of fasciculations- which means if there are ALS fasciculations – there will also be abnormal units – Is that true? And if not, how much time would it take for abnormal units to appear if there are already ALS fasciculations? (Weeks, months.)?įasciculations (at least Motor Neuron fascics) are a sign of ongoing reinnervation and can actually begin distally in regenerated nerve fibers. If the SNAP is abnormal consider a concomitant neuropathy of different etiology or revise your diagnosis to something other than ALS Abnormal motor units in ALS SNAPS or sensory nerve action potentials should be characteristically normal in ALS as the disease affects the anterior horn cell, (Amyotrophy) a motor neuron disease. While the compound muscle action potential (CMAP) is normal initially, but in advanced disease gets lower (even absent) due to severe loss of axons. The motor unit potential (MUP) gets higher in MND. What is the motor amplitude? Is it pathologically higher or lower than normal in ALS/MND?
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